QUANTIFERON-TB GOLD PLUS ASSAY SPECIFICITY IN CHILDREN AND ADOLESCENTS WITH SUSPECTED TUBERCULOSIS—A MULTICENTER CROSS-SECTIONAL STUDY IN SPAIN

QUANTIFERON-TB GOLD PLUS ASSAY SPECIFICITY IN CHILDREN AND ADOLESCENTS WITH SUSPECTED TUBERCULOSIS—A MULTICENTER CROSS-SECTIONAL STUDY IN SPAIN

In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, r...

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Bibliographic Details
Published in:The Pediatric infectious disease journal
Main Authors: Soler-Garcia, Aleix, Gamell, Anna, Santiago, Begoña, Monsonís, Manuel, Cobo-Vázquez, Elvira, Bustillo-Alonso, Matilde, Tagarro, Alfredo, Pérez-Gorricho, Beatriz, Espiau, María, Piqueras, Ana Isabel, Korta-Murua, José Javier, Rodríguez-Molino, Paula, Lobato, Zulema, Pérez-Porcuna, Tomàs, Tebruegge, Marc, Noguera-Julian, Antoni
Format: Journal Article
Language:English
Published: Wolters Kluwer Health, Inc. All rights reserved 22-07-2021
Online Access:Get full text
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Summary:In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.
ISSN:0891-3668
DOI:10.1097/INF.0000000000003173