Oral epithelial stem cells in tissue maintenance and disease:the first steps in a long journey

The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine. The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over time. When combined wi...

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Bibliographic Details
Published in:	国际口腔科学杂志（英文版） no. 3; pp. 121 - 129
Main Authors:	Kyle B Jones, Ophir D Klein
Format:	Journal Article
Language:	English
Published:	Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, San Francisco, USA 2013
Subjects:	cancer stem cell oral epithelial stem cell population asymmetry invariant asymmetry neutral drift
Online Access:	Get full text
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Summary:	The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine. The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over time. When combined with advanced mathematical and statistical methods, stem cell division dynamics can be studied in new and exciting ways. Despite advances in a number of tissues, relatively little attention has been paid to stem cells in the oral epithelium. This review will focus on current knowledge about adult oral epithelial stem cells, paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease.
ISSN:	1674-2818
DOI:	10.1038/ijos.2013.46;publishedonline26July2013