Effects of Physical Exercise on Lipid and Inflammatory Profile of Women Using Combined Oral Contraceptive: A Cross-Over Study

• Published in: International journal of cardiovascular sciences
• Main Authors: Gomes, Vinícius Afonso, Sacramento, Marvyn de Santana do, Cecilia, Lucas Mendes Santa, Jesus, Daniela Santos de, Barbosa, Juliane Santos, Almeida, Fernanda Oliveira Baptista de, Oliveira, Elaine Carvalho de, Petto, Jefferson
• Format: Journal Article
• Language: Portuguese
• Published: Sociedade Brasileira de Cardiologia 2022
• Subjects: CARDIAC & CARDIOVASCULAR SYSTEMS; Women; Risk Factors; Atherosclerosis; Contraceptives, Oral, Combined; Lipids; Inflammation; Physical Activity; High Intensity Interval Training
• ISSN: 2359-5647; 2359-5647
• DOI: 10.36660/ijcs.20200399

Abstract Background: The use of combined oral contraceptives (COC) is a risk factor for atherosclerotic disease, and physical exercise can minimize this condition. Objective: To verify if high intensity interval training (HIIT) promotes changes in the lipid and inflammatory profile of women using COC. Methods: Sequential crossover study with women aged 20-30 years, classified as irregularly active by the international physical activity questionnaire (IPAQ), when using COC. A physical-clinical assessment was performed with anthropometric measurements, VO2max, and analysis of lipid and inflammatory profile. Participants were divided into 2 groups: the initial intervention group (GII), which began practicing HIIT for 2 months, and the posterior intervention group (GIP), which remained inactive for the same period. The GII and GIP would then alternate their conditions. The collected data was divided into: Initial moment (IM), post-exercise moment (PEM) and post-inactivity (PIM). The statistical analyses were performed using the Statistical Package for the Social Sciences, adopting a significance level of p <0.05 . Results: Twelve women were evaluated. After crossing the GII and GIP data, there was a difference in the C-reactive protein values between the IM of 4 (1.6-6.3 mg/dL) vs. PEM 2 (1.5-5 mg/dL); as well as between the PEM vs. the PIM= 4 (1.5-5.8 mg/dL), with a p -value = 0.04 in the comparisons. There was no change between the “moments” of the lipid profile, although it was possible to notice a reduction in resting HR and an increase in indirect VO2max. Conclusion: The HIIT program was able to reduce the inflammatory profile, but it did not alter the lipid profile of irregularly active women using COC.