A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationElectronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationElectronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibi...

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Bibliographic Details
Main Authors: Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T. D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil
Format: Journal Article
Language:English
Published: 27-06-2016
Online Access:Get full text
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Summary:Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication. A novel hybrid able to protect organophosphate-inhibited AChE as well as to reactivate it.
Bibliography:10.1039/c6tx00130k
Electronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI
ISSN:2045-452X
2045-4538
DOI:10.1039/c6tx00130k