Reaction discovery using acetylene gas as the chemical feedstock accelerated by the “stop-flow” micro-tubing reactor system† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00408g

• Published in: Chemical science (Cambridge) Vol. 8; no. 5; pp. 3623 - 3627
• Main Authors: Xue, Fei, Deng, Hongping, Xue, Chengwen, Mohamed, Dara Khairunnisa Binte, Tang, Karen Yuanting, Wu, Jie
• Format: Journal Article
• Language: English
• Published: Royal Society of Chemistry 27-02-2017
• Subjects: Chemistry
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/c7sc00408g

A “stop-flow” micro-tubing reactor system was designed for accelerating reaction discovery using flammable acetylene gas as the feedstock.
Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of “stop-flow” micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this “stop-flow” micro-tubing reactor system.