NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection
Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity antibodies. Here we show that deficiency in NFAT1 and NFAT2 in CD4 + T cells leads to impaired germinal center reactions upon vira...
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Published in: | The Journal of immunology (1950) Vol. 196; no. 5; pp. 2015 - 2019 |
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Main Authors: | , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
05-02-2016
|
Online Access: | Get full text |
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Summary: | Follicular helper T (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity antibodies. Here we show that deficiency in NFAT1 and NFAT2 in CD4
+
T cells leads to impaired germinal center reactions upon viral infection due to reduced Tfh cell differentiation and defective expression of proteins involved in T:B interactions and B cell help, including ICOS, PD-1, and SLAM family receptors. ChIP-seq data suggest that NFAT proteins likely directly participate in regulation of genes important for Tfh cell differentiation and function. NFAT proteins are important TCR and Ca
2+
-dependent regulators of T cell biology, and here we demonstrate a major positive role of NFAT family members in Tfh differentiation. |
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Bibliography: | Present address: Department of Microbiology and Immunology. The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA. Present address: Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil. |
ISSN: | 0022-1767 1550-6606 |
DOI: | 10.4049/jimmunol.1501841 |