Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food IntakeBrown Adipose Tissue in Rats

• Published in: Nutrients Vol. 1; no. 2; pp. 178 - 196
• Main Authors: Sneddon, Alan A., Rayner, D. Vernon, Mitchell, Sharon E., Bashir, Shabina, Ha, Jung-Heun, Wahle, Klaus W., Morris, Amanda C., Williams, Lynda M.
• Format: Journal Article
• Language: English
• Published: Molecular Diversity Preservation International 26-11-2009
• ISSN: 2072-6643
• DOI: 10.3390/nu1020178

The effect of supplementation with 1% conjugated linoleic acid and 1%
n
-3 long chain polyunsaturated fatty acids (CLA/
n
-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/
n
-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.