Primary culture of different renal cell carcinoma cells with respect to immunomodulatory effects

The presented results show that renal cell carcinomas (RCC) have partial immunomodulatory capacity (production of cytokines as IL-6, -10, -11; modulation of mitogen-induced transformation of T lymphocytes). The production of IL-10 shows a tendency to correlate with higher staging and grading of RCC....

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Bibliographic Details
Published in:	Immunitat und Infektion Vol. 23; no. 2; p. 72
Main Authors:	Knöfel, B, Junker, U, Nuske, K, el-Seweifi, A, Junker, K, Kosmehl, H, Jäger, L
Format:	Journal Article
Language:	German
Published:	Germany 01-04-1995
Subjects:	Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Culture Media Humans In Vitro Techniques Interleukin-10 - metabolism Interleukin-10 - pharmacology Interleukin-11 - metabolism Interleukin-11 - pharmacology Interleukin-6 - metabolism Interleukin-6 - pharmacology Lymphocyte Activation Tumor Cells, Cultured
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Summary:	The presented results show that renal cell carcinomas (RCC) have partial immunomodulatory capacity (production of cytokines as IL-6, -10, -11; modulation of mitogen-induced transformation of T lymphocytes). The production of IL-10 shows a tendency to correlate with higher staging and grading of RCC. The cytokine production does not correlate with specific types of RCC. Direct immunosuppression of T lymphocytes in lymphocyte transformation tests (LTT) was not detectable.