Emerging Role of 18 F-NaF PET/Computed Tomographic Imaging in Osteoporosis: A Potential Upgrade to the Osteoporosis Toolbox

Osteoporosis is a metabolic bone disorder that leads to a decline in bone microarchitecture, predisposing individuals to catastrophic fractures. The current standard of care relies on detecting bone structural change; however, these methods largely miss the complex biologic forces that drive these s...

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Bibliographic Details
Published in:	PET clinics Vol. 18; no. 1; p. 1
Main Authors:	Sheppard, Aaron J, Paravastu, Sriram S, Wojnowski, Natalia M, Osamor, 3rd, Charles C, Farhadi, Faraz, Collins, Michael T, Saboury, Babak
Format:	Journal Article
Language:	English
Published:	United States 01-01-2023
Subjects:	Fractures, Bone Humans Osteoporosis - diagnostic imaging Positron Emission Tomography Computed Tomography Sodium Fluoride Tomography, X-Ray Computed Osteoporosis Sodium fluoride (F-NaF) PET/CT Bone mineral density Bone Turnover Bone Metabolism
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Summary:	Osteoporosis is a metabolic bone disorder that leads to a decline in bone microarchitecture, predisposing individuals to catastrophic fractures. The current standard of care relies on detecting bone structural change; however, these methods largely miss the complex biologic forces that drive these structural changes and response to treatment. This review introduces sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) as a powerful tool to quantify bone metabolism. Here, we discuss the methods of 18F-NaF PET/CT, with a special focus on dynamic scans to quantify parameters relevant to bone health, and how these markers are relevant to osteoporosis.
ISSN:	1879-9809