Self-Confirming Magnetosomes for Tumor-targeted T 1 /T 2 Dual-Mode MR Imaging and MRI-Guided Photothermal Therapy

Nanomaterials as T /T dual-mode magnetic resonance imaging (MRI) contrast agents have great potential in improving the accuracy of tumor diagnosis. Applications of such materials, however, are limited by the complicated chemical synthesis process and potential biosafety issues. In this study, we rep...

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Bibliographic Details
Published in:	Advanced healthcare materials p. e2200841
Main Authors:	Jiang, Gexuan, Fan, Di, Tian, Jiesheng, Xiang, Zhichu, Fang, Qiaojun
Format:	Journal Article
Language:	English
Published:	Germany 17-05-2022
Subjects:	PTT MRI tumor biosynthesis Mn-doping dual-mode magnetosome
Online Access:	Get full text
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Summary:	Nanomaterials as T /T dual-mode magnetic resonance imaging (MRI) contrast agents have great potential in improving the accuracy of tumor diagnosis. Applications of such materials, however, are limited by the complicated chemical synthesis process and potential biosafety issues. In this study, we report the biosynthesis of manganese (Mn)-doped magnetosomes (MagMn) that not only can be used in T /T dual-mode MR imaging with self-confirmation for tumor detection, but also improve the photothermal conversion efficiency for MRI-guided photothermal therapy (PTT). The MagMn nanoparticles are naturally produced through the biomineralization of magnetotactic bacteria by doping Mn into the ferromagnetic iron oxide crystals. In vitro and in vivo studies demonstrated that targeting peptides functionalized MagMn enhanced both T and T MRI signals in tumor tissue and significantly inhibited tumor growth by the further MRI-guided PTT. We envision that the biosynthesized multifunctional MagMn nanoplatform may serve as a potential theranostic agent for cancer diagnosis and treatment. This article is protected by copyright. All rights reserved.
ISSN:	2192-2659