OXA-CuS@UiO-66-NH 2 as a drug delivery system for Oxaliplatin to colorectal cancer cells

In this work, UiO-66-NH was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH . To chara...

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Bibliographic Details
Published in:	Journal of materials science. Materials in medicine Vol. 33; no. 3; p. 26
Main Authors:	Gholami, Marjan, Hekmat, Azadeh, Khazaei, Majid, Darroudi, Majid
Format:	Journal Article
Language:	English
Published:	United States 28-02-2022
Subjects:	Colorectal Neoplasms - drug therapy Copper Drug Delivery Systems Humans Metal-Organic Frameworks Oxaliplatin - pharmacology Oxaliplatin - therapeutic use Phthalic Acids Spectroscopy, Fourier Transform Infrared
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Summary:	In this work, UiO-66-NH was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH . To characterize and investigate their cytotoxicity effects, powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) analysis, UV-Visible analysis, inductively coupled plasma mass spectrometry (ICP-MS), and MTT assay were considered to be performed. According to the observations, the cytotoxicity of OXA-CuS@UiO-66-NH was greater than that of the OXA alone.
ISSN:	1573-4838