Biocompatibility, antioxidant activity and collagen photoprotection properties of C 60 fullerene adduct with L-methionine

• Published in: Nanomedicine Vol. 40; p. 102500
• Main Authors: Sharoyko, Vladimir V, Shemchuk, Olga S, Meshcheriakov, Anatolii A, Vasina, Lubov V, Iamalova, Nailia R, Luttsev, Michail D, Ivanova, Daria A, Petrov, Andrey V, Maystrenko, Dmitriy N, Molchanov, Oleg E, Semenov, Konstantin N
• Format: Journal Article
• Language: English
• Published: United States 01-02-2022
• Subjects: Antioxidants - pharmacology; Collagen - pharmacology; Fullerenes - chemistry; Fullerenes - pharmacology; Humans; Methionine - pharmacology; Water; L-Methionine; Ultra-violet light; Collagen; Fullerenes; Biological activity
• ISSN: 1549-9642

Functionalization of the fullerene core with amino acids has become a new and promising direction in the field of nanochemistry. The biologic activity of water-soluble fullerene derivatives is based on such properties as lipophilicity, electron deficiency and photosensitivity. The complex of above-mentioned properties can be used to develop protection of biomolecules (in particular, proteins) from external physical and chemical influences. Thus, development and up-scaling of synthesis procedures, as well as investigation of the biological properties of these derivatives, are extremely important. This paper presents new data on the biocompatibility studies of C
fullerene adduct with L-methionine (C
[C
H
NO
S]
; C
-Met). Antiradical activity, binding to human serum albumin (HSA), collagen and deoxyribonucleic acid (DNA), hemocompatibility, photodynamic properties, genotoxicity and cytotoxicity were studied. In addition, it was found that C
-Met increases the photostability of the collagen molecule, and this effect is dose-dependent.