Association of CHA 2 DS 2 -VASc score with thrombus burden in patients with acute myocardial infarction undergoing SVG-PCI

Association of CHA 2 DS 2 -VASc score with thrombus burden in patients with acute myocardial infarction undergoing SVG-PCI

The rate of saphenous vein graft (SVG) occlusion within the first year of bypass graft surgery is 15%. The CHA DS -VASc score is used to predict the risk of thromboembolic events in patients with nonvalvular atrial fibrillation. We aimed to evaluate the predictive role of the CHA DS -VASc score in t...

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Bibliographic Details
Published in:Herz
Main Authors: Maden, Orhan, Çakmak Karaaslan, Özge, Kanal, Yücel, Yakut, İdris, Yaman, Nezaket Merve, Könte, Hasan Can, Balcı, Kevser Gülcihan, Selçuk, Mehmet Timur, Selçuk, Hatice
Format: Journal Article
Language:English
Published: Germany 04-10-2021
Subjects:
No-reflow
CHA2DS2-VASc score
Thrombus burden
Saphenous vein graft disease
Coronary artery bypass graft
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Summary:The rate of saphenous vein graft (SVG) occlusion within the first year of bypass graft surgery is 15%. The CHA DS -VASc score is used to predict the risk of thromboembolic events in patients with nonvalvular atrial fibrillation. We aimed to evaluate the predictive role of the CHA DS -VASc score in the estimation of intracoronary thrombus burden in patients with acute myocardial infarction (AMI) who underwent SVG-PCI. We retrospectively evaluated 221 patients who were admitted with AMI and underwent PCI of SVGs at the Department of Cardiology in the Turkiye Yuksek Ihtisas Education and Research Hospital between 2012 and 2018. The study population was divided into two groups according to their Thrombolysis in Myocardial Infarction (TIMI) thrombus grade: low thrombus burden (LTB; TIMI 0-3) and high thrombus burden (HTB; TIMI 4 and 5). The study included 221 patients with a mean age of 63.3 ± 6.7 years. The patients with HTB had significantly higher CHA DS -VASc scores (p < 0.001) compared with LTB patients. Univariate and multivariate regression analysis demonstrated that both CHA DS -VASc score (OR: 1.573, 95% CI: 1.153-2.147, p = 0.004) as a continuous variable and a binary cut-off level of the CHA DS -VASc score > 3 (OR: 3.876, 95% CI: 1.705-8.808, p = 0.001) were significantly associated with HTB. The ability of the CHA DS -VASc score to predict HTB burden was evaluated by receiver-operating characteristics analysis curve analysis. The optimum cut-off value of the CHA DS -VASc score for predicting HTB was 3 (with a sensitivity of 67.9% and a specificity of 69.3%) according to the Youden index. The CHA DS -VASc score can be used as an easy practical tool to predict HTB in AMI patients undergoing SVG-PCI.
ISSN:1615-6692