Enamel erosion control by strontium-containing TiO 2 - and/or MgO-doped phosphate bioactive glass

• Published in: Clinical oral investigations Vol. 26; no. 2; p. 1915
• Main Authors: Nyland, Berthyelle Pádova, Pereira, Cristiano Porcel, Soares, Paulo, da Luz Weiss, Denise Stolle, Mikos, Walter Luís, Brancher, João Armando, Vieira, Sérgio, Freire, Andrea
• Format: Journal Article
• Language: English
• Published: Germany 01-02-2022
• Subjects: Dental Enamel; Glass; Humans; Magnesium Oxide; Phosphates; Strontium; Titanium; Tooth Erosion - prevention & control; Bioactive glass; Enamel erosion; Roughness; Microhardness; Profilometry; Bioglass 45S5
• ISSN: 1436-3771

To evaluate the effect of strontium-containing titanium- and/or magnesium-doped phosphate bioactive glass on the control of dental erosion.
Fifty fragments of human enamel were divided into five groups: negative control, 45S5 bioglass, strontium-containing Ti-doped phosphate bioactive glass (PBG-Ti), strontium-containing Mg-doped phosphate bioactive glass (PBG-Mg), and strontium-containing Ti- and Mg-doped phosphate bioactive glass (PBG-TiMg). The specimens underwent cycles of erosive challenge twice daily for 5 days with 1 mL of citric acid for 2 min followed by 1 mL of the suspension with bioactive substances for 3 min. After the cycles, profilometry, roughness and microhardness testing, and scanning electron microscopy (SEM) were performed. The following statistical tests were used: one-way ANOVA (profile, roughness, and surface microhardness (%VMS) data variation), Tukey's HSD (%VMS), Games-Howell test (profilometry), Student's t test (roughness), and Pearson's correlation between the variables.
The lower loss of enamel surface and lower %VMS was observed in the PBG-Mg and PBG-TiMg groups, and only the PBG-Mg group showed similar roughness between baseline and eroded areas (p > 0.05). On SEM micrographs, PBG-Ti and PBG-Mg groups showed lower apparent demineralization.
All bioactive materials protected the enamel against erosion. However, strontium-containing phosphate bioactive glasses showed lower enamel loss, and the presence of Mg in these bioactive glasses provided a greater protective effect.
Experimental strontium-containing phosphate bioactive glasses are effective in controlling enamel erosion. The results obtained in this study will guide the development of new dental products.