A randomized controlled study of vaginal fractional CO 2 laser therapy for female sexual dysfunction

• Published in: Lasers in medical science Vol. 37; no. 1; p. 359
• Main Authors: Lou, Wenjia, Chen, Fei, Xu, Tao, Fan, Qingbo, Shi, Honghui, Kang, Jia, Shi, Xinwen, Zhu, Lan
• Format: Journal Article
• Language: English
• Published: England 01-02-2022
• Subjects: Carbon Dioxide; Female; Humans; Laser Therapy; Lasers, Gas - therapeutic use; Sexual Dysfunction, Physiological; Vagina; Kegel exercises; Sexually active women; Fractional CO2 laser therapy; Female sexual dysfunction; Female Sexual Function Index
• ISSN: 1435-604X

The purpose of this study is to evaluate the efficacy and safety of vaginal fractional CO
laser therapy for female sexual dysfunction (FSD). A total of 84 women at high risk of sexual dysfunction were randomly divided into two groups. Women in the laser group received vaginal fractional CO
laser therapy. Others in the Kegel group were advised to participate in Kegel exercise training. Sexual distress and sexual function were evaluated by using the Female Sexual Distress Scale-Revised (FSDS-R) and the Chinese version Female Sexual Function Index (CVFSFI), respectively. Adverse events were recorded during the 12-month follow-up. At the end of the 6th and 12th months, the lubrication scores of the CVFSFI in the laser group (4.55±0.05, 4.58±0.09) were significantly higher than those in the Kegel group (4.19±0.15, 4.20±0.14) (P<0.05). The satisfaction scores in the laser group (4.43±0.08) were higher than those in the Kegel group (4.20±0.16) at the end of the 6th month (P<0.05). The self-contrast test in the laser group showed significant improvement in lubrication, pain, satisfaction and total scores after CO
laser therapy (p<0.05). These improvements were maintained for 1 year. The improvement of FSDS-R in the laser group (10.0±0.2) was more evident than in the Kegel group (11.1±0.4) at the end of the 12th month. There were no major adverse events reported during laser therapy. Vaginal fractional CO
laser therapy can effectively improve sexual function without any serious adverse events. It might be an effective and relatively safe treatment option for improving vaginal mucosa status in sexually active women with sexual dysfunction.