Intracellular Ca 2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria

Ca signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca storage inside the cell, but mitochondria have long been recognized as a fundamental Ca pool. Proto...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 1
Main Authors:	Scarpelli, Pedro H, Pecenin, Mateus F, Garcia, Celia R S
Format:	Journal Article
Language:	English
Published:	Switzerland 05-01-2021
Subjects:	Animals Calcium - metabolism Calcium Signaling - physiology Eukaryota - metabolism Humans Mitochondria - metabolism Parasites - metabolism Plasmodium falciparum - metabolism Protozoan Proteins - metabolism Toxoplasma - metabolism Trypanosoma cruzi - metabolism mitochondria calcium signaling protozoan parasites
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Summary:	Ca signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca storage inside the cell, but mitochondria have long been recognized as a fundamental Ca pool. Protozoan parasites such as , , and display a Ca signaling toolkit with similarities to higher eukaryotes, including the participation of mitochondria in Ca -dependent signaling events. This review summarizes the most recent knowledge in mitochondrial Ca signaling in protozoan parasites, focusing on the mechanism involved in mitochondrial Ca uptake by pathogenic protists.
ISSN:	1422-0067