The mouse paw edema test for titrating Shigella toxin and antitoxin and for determining the safety of the anatoxin

The method for the titration of Shigella dysenteriae I neurotoxin, toxoid prepared from this toxin and different antitoxic preparations in the mouse paw edema test has been developed. The quantitative determination of antitoxin is based on the neutralization test. The conditions of titration (the di...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 7; p. 68
Main Authors:	Kamzolkina, N B, Volkov, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1987
Subjects:	Animals Antitoxins - immunology Colostrum - immunology Dose-Response Relationship, Immunologic Edema - chemically induced Female Foot Goats - immunology Immunization Mice Milk - immunology Neurotoxins - immunology Neutralization Tests - methods Shigella dysenteriae Toxoids - immunology
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Summary:	The method for the titration of Shigella dysenteriae I neurotoxin, toxoid prepared from this toxin and different antitoxic preparations in the mouse paw edema test has been developed. The quantitative determination of antitoxin is based on the neutralization test. The conditions of titration (the dilutions of the neurotoxin and the neutralization doses of the antitoxin), as well as criteria for the evaluation of the positive or negative results, have been established.
ISSN:	0372-9311