Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle

• Published in: Natural product research p. 1
• Main Authors: Tegasne, Catherine, Kapche, Gilbert Deccaux Wabo Fotso, Mawabo, Isabelle Kamga, Talla, Rostan Mangoua, Jouda, Jean-Bosco, Happi, Gervais Mouthé, Lenta, Bruno Ndjakou, Frese, Marcel, Abegaz, Berhanu Molah, Sewald, Norbert
• Format: Journal Article
• Language: English
• Published: England 30-07-2020
• Subjects: Burceraceae; dalzienoside; bioguided; Boswellia dalzielii; Antibacterial
• ISSN: 1478-6427

Stem barks of
are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH
Cl
(1/1, v/v) stem barks extract led to the isolation of fourteen compounds
, identified based on spectroscopic data. Dalzienoside (
is reported here for the first time. The broth microdilution method was used to evaluate the antibacterial activity of the crude extract, fractions and compounds against six bacterial strains. The crude extract exhibited moderate antibacterial activity with MIC of 250 μL/ml; two fractions showed significant activities with MICs ranging from 7.8 to 125 μg/ml, while
-boswellic acid (
),
-boswellic acid (
), acetyl-11-keto-
-boswellic acid (
) from these fractions exhibited strong activities with MIC value of 3.125 µg/mL against
and
. This study gives insight into the antibacterial constituents of the stem bark of
and justifies its use in ethnomedicine.