Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-( Trans -2-Phenylcyclopropyl)-1 H -Indole-3-Carboxylate

Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-( Trans -2-Phenylcyclopropyl)-1 H -Indole-3-Carboxylate

Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 50; no. 4; p. 489
Main Authors: Balzarini, J, Ruchko, E A, Zakharova, E K, Kameneva, I Yu, Nawrozkij, M B
Format: Journal Article
Language:English
Published: United States 2014
Subjects:
umifenovir
antiviral activity
conformationally restricted analogs
Online Access:Get full text
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Summary:Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.
ISSN:0009-3122