68 Ga-PSMA-PET/CT and Diffusion MRI Targeting for Cone-Beam CT-Guided Bone Biopsies of Castration-Resistant Prostate Cancer Patients

• Published in: Cardiovascular and interventional radiology Vol. 43; no. 1; p. 147
• Main Authors: van Steenbergen, T R F, Smits, M, Scheenen, T W J, van Oort, I M, Nagarajah, J, Rovers, M M, Mehra, N, Fütterer, J J
• Format: Journal Article
• Language: English
• Published: United States 01-01-2020
• Subjects: Aged; Bone and Bones - diagnostic imaging; Bone and Bones - pathology; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - pathology; Bone Neoplasms - secondary; Cone-Beam Computed Tomography - methods; Diffusion Magnetic Resonance Imaging - methods; Edetic Acid - analogs & derivatives; Humans; Image-Guided Biopsy; Male; Middle Aged; Oligopeptides; Pilot Projects; Positron Emission Tomography Computed Tomography - methods; Prospective Studies; Prostatic Neoplasms, Castration-Resistant - pathology; Radiography, Interventional - methods; Reproducibility of Results; Bone biopsy; Cone-beam CT; Diffusion MRI; Molecular analysis; Castration resistant prostate cancer; PSMA-PET/CT
• ISSN: 1432-086X

Precision medicine expands the treatment options for metastatic castration-resistant prostate cancer (mCRPC) by targeting druggable genetic aberrations. Aberrations can be identified following molecular analysis of metastatic tissue. Bone metastases, commonly present in mCRPC, hinder precision medicine due to a high proportion of biopsies with insufficient tumor cells for next-generation DNA sequencing. We aimed to investigate the feasibility of incorporating advanced target planning and needle guidance in bone biopsies and whether this procedure increases biopsy tumor yield and success rate of molecular analysis as compared to the current standards, utilizing only CT guidance.
In a pilot study, ten mCRPC patients received
Ga-prostate-specific membrane antigen (PSMA)-PET/CT and diffusion-weighted MRI as biopsy planning images. These datasets were fused for targeting metastatic lesions with high tumor densities. Biopsies were performed under cone-beam CT (CBCT) guidance. Feasibility of target planning and needle guidance was assessed, and success of molecular analysis and tumor yield were reported.
Fusion target planning and CBCT needle guidance were feasible. Nine out of ten biopsies contained prostate cancer cells, with a median of 39% and 40% tumor cells by two different sequencing techniques. Molecular analysis was successful in eight of ten patients (80%). This exceeds previous reports on CT-guided biopsies that ranged from 33 to 44%. In two patients, important druggable aberrations were found.
A biopsy procedure using advanced target planning and needle guidance is feasible and can increase the success rate of molecular analysis in bone metastases, thereby having the potential of improving treatment outcome for patients with mCRPC.
Level 4, case series.