Molecular markers of the oral mucosa damage in patients with leukemia.

• Published in: Klinicheskaia laboratornaia diagnostika Vol. 63; no. 6; p. 349
• Main Authors: Selezneva, I A, Svechnikova, M V, Gilmiyarov, E M, Gusyakova, O A, Gilmiyarova, F N, Kuznetsova, O Yu
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2018
• Subjects: Autoantibodies - blood; Biomarkers - blood; GTP-Binding Proteins - immunology; Humans; Immunoglobulin A - blood; Immunoglobulin G - blood; Leukemia - pathology; Mouth Mucosa - pathology; Transglutaminases - immunology; acute and chronic leukemia; IgA antibodies to transglutaminase and gliadin; stomatitis; oral fluid; IgG antibodies to transglutaminase and gliadin
• ISSN: 0869-2084

The criteria for early manifestations of mucosal lesions in patients with acute and chronic leukemia are distinguished: in the absence of complaints and changes in the index assessment of the oral cavity, a block of initial dental signs in the form of edema of the tongue and the smoothness of its papillae, pallor of the oral mucosa in patients with leukemia. In theoral fluid of patients with the initial signs of dental pathology in acute leukemia, a specific spectrum of disorders was established in the form of the lowest antibody level of immunoglobulin A class to transglutaminase in combination with a high amount of Ig G antibodies to transglutaminase - 8.73 ± 0.92 U / ml, which maximal level exceeds the reference limits by almost 4 times (38.80 U / ml) - that indicates structural changes in the connective tissues of the oral cavity. Under the influence of chemotherapy in these patients, the inversion of clinical manifestations of dental pathology was noted: stomatitis II (medium) severity is formed, bypassing I degree, accompanied by a 4-fold increase of IgA antibodies to transglutaminase (4.03 ± 0, 77 U / ml, p < 0.05) in the oral fluid of patients with acute leukemia and 2.5 times for chronic leukemias (3.24 ± 0.47 U / ml, p < 0.05) compared to pre-treatment period. In this regard, it is recommended to determine the content in the oral fluid for antibodies to transglutaminase in patients with leukemia for verification of the degree of inflammatory-destructive process and its recovery. The peculiarity of immunological shifts in stomatitis of the 1st degree of severity is the highest level of IgG antibodies to transglutaminase (9.98 ± 1.50 U / ml) in the oral fluid, and at II-III degree the molecular manifestations of damage are smoother, which indicates the depression of immune processes.