Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence [Short communication]

Interleukin (IL) 10 and interferon-gamma (IFN-) levels in induced sputum supernatants of 21 tuberculosis (TB) patients at diagnosis and during chemotherapy were correlated to recurrence rates. IL-10 decreased until day 60 of treatment (T60), and between T60 and T180 it increased again in 7 cases (Pa...

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Bibliographic Details
Published in:	The international journal of tuberculosis and lung disease Vol. 16; no. 5; p. 656
Main Authors:	Lago, P M, Boéchat, N, Migueis, D P, Almeida, A S, Lazzarini, L C, Saldanha, M M, Kritski, A L, Ho, J L, Lapa E Silva, J R
Format:	Journal Article
Language:	English
Published:	France 01-05-2012
Online Access:	Get full text
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Summary:	Interleukin (IL) 10 and interferon-gamma (IFN-) levels in induced sputum supernatants of 21 tuberculosis (TB) patients at diagnosis and during chemotherapy were correlated to recurrence rates. IL-10 decreased until day 60 of treatment (T60), and between T60 and T180 it increased again in 7 cases (Pattern 1) and further decreased in 14 cases (Pattern 2). Follow-up of 69 months was performed in 20/21 cases; 6 had recurrence of TB, of which 5/7 (71%) had Pattern 1 and 1/13 (7.7%) Pattern 2 (OR 30.0, 95%CI 2.19411.3, P 0.0072). This was not observed for IFN-. High IL-10 levels at the end of treatment may function as a risk factor for TB recurrence.
ISSN:	1815-7920