Pathogenic properties of freshly isolated strains of the pertussis microbe

The serovar composition, toxicity, virulence and lymphocytosis stimulating activity (LSA) of B. pertussis strains circulating in the 1980-ies were studied in comparison with the strains circulating in previous years. The study revealed changes in the toxic properties of B. pertussis: their decrease...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 3; p. 10
Main Authors:	Shakirova, R G, Kuznetsova, L S, Kondrat'eva, A M, Tsipkin, V I, Korobova, L M
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1988
Subjects:	Animals Bordetella pertussis - classification Bordetella pertussis - isolation & purification Bordetella pertussis - pathogenicity Humans Lethal Dose 50 Leukocyte Count Mice Mice, Inbred C57BL Mice, Inbred CBA Serotyping Virulence Whooping Cough - microbiology
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Summary:	The serovar composition, toxicity, virulence and lymphocytosis stimulating activity (LSA) of B. pertussis strains circulating in the 1980-ies were studied in comparison with the strains circulating in previous years. The study revealed changes in the toxic properties of B. pertussis: their decrease in the years of the intensive immunization of children against whooping cough and rise at the period when the number of immunized children was reduced. The toxic properties and LSA in most B. pertussis strains were less pronounced in the 1980-ies than in the 1960-ies. The serovar composition of the circulating strains remained stable for 15 years with the prevalence of serovar 1.0.3.
ISSN:	0372-9311