Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines

Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and S-isomers of 3-MeSpd for th...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 41; no. 5; p. 612
Main Authors:	Khomutov, M A, Keinanen, T A, Hyvonen, M T, Weisell, J, Vepsalainen, J, Alhonen, L, Kochetkov, S N, Khomutov, A R
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2015
Subjects:	Catalysis Cell Line, Tumor Humans Molecular Structure Oxidoreductases Acting on CH-NH Group Donors - chemistry Spermidine - analogs & derivatives Spermidine - chemical synthesis Spermidine - chemistry Spermidine - metabolism Stereoisomerism
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Summary:	Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and S-isomers of 3-MeSpd for the investigation of the stereospecificity of spermidine transporter and peculiarities of deoxyhypusine synthase reaction are discussed.
ISSN:	0132-3423