Hypoxia-inducible factor 1α in breast cancer prognosis

• Published in: Clinica chimica acta
• Main Authors: Wang, Wei, He, Yi-Fu, Sun, Qi-Kai, Wang, Yong, Han, Xing-Hua, Peng, Deng-Fu, Yao, Yi-Wei, Ji, Chu-Shu, Hu, Bing
• Format: Journal Article
• Language: English
• Published: Netherlands 25-10-2013
• Subjects: Prognosis; Breast cancer; HIF-1α; Meta-analysis
• ISSN: 1873-3492

Recent studies have assessed the relationship between hypoxia-inducible factor 1α (HIF-1α) expression and prognosis in breast cancer patients with inconsistent conclusions. To comprehensively and quantitatively summarize the evidence on the survival of patients with breast cancer, a meta-analysis was performed.
Systematic literature searching were applied to the databases of PubMed, Embase and Web of science until April 1, 2013. Pooled HR with 95% CI was used to evaluate the association between HIF-1α expression and survival in breast cancer patients.
14 papers including 2933 patients were subjected to the final analysis. Of these, 7 provided data on overall survival (OS), 8 on disease-free survival (DFS), 3 on distant metastasis-free survival (DMFS) and 3 on relapse-free survival (RFS). We observed high expression of HIF-1α in breast cancer patients was an indicator of poor prognosis on OS (HR=1.46, 95% CI: 1.12-1.92, P=0.006), DFS (HR=1.91, 95% CI: 1.43-2.57, P<0.001), DMFS (HR=2.17 95% CI: 1.16-4.05, P=0.015) and RFS (HR=1.33 95% CI:1.09-1.61, P=0.005). Significant heterogeneity was observed in the analyses of OS and DFS. Subgroup analyses by the cut-off value and antibody for IHC were conducted.
High expression of HIF-1α indicated a poor prognosis for patients with breast cancer.