Endoplasmic reticulum stress, its sensor and signalling systems and the role in regulation of gene expression at malignant tumor growth and hypoxia

Hypoxia is one of the inductors of the expression of a large group of genes, which control glycolysis and proliferation processes in low oxygen conditions or as a result of low oxygen consumption. Moreover, hypoxia is one of the factors which induce the endoplasmic reticulum stress which, like hypox...

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Bibliographic Details
Published in:	Ukrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 85; no. 5; p. 5
Main Authors:	Minchenko, O H, Khar'kova, A P, Bakalets', T V, Kryvdiuk, I V
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 01-09-2013
Subjects:	Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Animals Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell Proliferation eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - genetics Endoribonucleases - genetics Endoribonucleases - metabolism Gene Expression Regulation, Neoplastic Glycolysis Humans Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction
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Summary:	Hypoxia is one of the inductors of the expression of a large group of genes, which control glycolysis and proliferation processes in low oxygen conditions or as a result of low oxygen consumption. Moreover, hypoxia is one of the factors which induce the endoplasmic reticulum stress which, like hypoxia, is an obligatory component of malignant tumor growth and is connected with cytoplasm and nuclei through three sensor and signalling systems: PERK, ATF6 (Ta) ERN1. The suppression of ERNI, the main sensing and signalling enzyme of endoplasmic reticulum stress, leads to a decrease of tumor growth and changes the character of hypoxic regulation of many genes responsible for the control of proliferation and glycolysis. ERN1 sensing and signalling system controls the expression of a large set of genes, which are dependent on endoplasmic reticulum stress as well as hypoxia. Moreover, this signalling pathway is an important factor of malignant tumor growth.