Treatment of intrabony defects with anorganic bone matrix/p-15 or guided tissue regeneration in patients with aggressive periodontitis

• Published in: Brazilian dental journal Vol. 24; no. 3; p. 204
• Main Authors: Queiroz, Adriana C, Nóbrega, Priscila Brasil da, Oliveira, Fabíola S, Novaes, Jr, Arthur B, Taba, Jr, Mário, Palioto, Daniela B, Grisi, Márcio F M, Souza, Sergio L S
• Format: Journal Article
• Language: English
• Published: Brazil 2013
• Subjects: Adolescent; Adult; Aggressive Periodontitis - surgery; Alveolar Bone Loss - surgery; Alveolar Process - diagnostic imaging; Bone Density - physiology; Bone Matrix - transplantation; Collagen - therapeutic use; Follow-Up Studies; Gingival Crevicular Fluid - chemistry; Guided Tissue Regeneration, Periodontal - methods; Humans; Interleukin-1beta - analysis; Interleukin-6 - analysis; Membranes, Artificial; Peptide Fragments - therapeutic use; Periodontal Attachment Loss - surgery; Periodontal Pocket - surgery; Radiography; Subtraction Technique; Surgical Flaps - surgery; Treatment Outcome; Young Adult
• ISSN: 1806-4760

Intrabony periodontal defects present a particular treatment problem, especially in patients with generalized aggressive periodontitis (G-AgP). Regenerative procedures have been indicated for this clinical situation. The aim of this study was to compare treatment outcomes of intrabony periodontal defects with either anorganic bone matrix/cell binding peptide (ABM/P-15) or guided tissue regeneration (GTR) in patients with G-AgP. Fifteen patients, with two intrabony defects ≥3 mm deep, were selected. Patients were randomly allocated to be treated with ABM/P-15 or GTR. At baseline and at 3 and 6 months after surgery, clinical and radiographic parameters and IL-1β and IL-6 gingival fluid concentrations were recorded. There was a significant probing pocket depth reduction (p<0.001) for both groups (2.27 ± 0.96 mm for ABM/P-15 group and 2.57 ± 1.06 mm for GTR group). Clinical attachment level gain (1.87 ± 0.94 mm for ABM/P-15 group and 2.09 ± 0.88 mm for GTR group) was also observed. There were no statistically significant differences in clinical parameters between the groups. The radiographic bone fill was more expressive in ABM/P-15 group (2.49 mm) than in GTR group (0.73 mm). In subtraction radiographs, the areas representing gain in density were 93.16% of the baseline defect for ABM/P-15 group versus 62.03% in GRT group. There were no statistically significant differences in inter-group and intra-group comparisons with regards to IL-1β and IL-6 quantification. Treatment of intrabony periodontal defects in patients with G-AgP with ABM/P-15 and GTR improved significantly the clinical outcomes. The use of ABM/P-15 promoted a better radiographic bone fill.