Use of BRAF V600E mutation in the differential diagnosis of follicular and papillary tumors of the thyroid and for the optimization of thearpy

• Published in: Voprosy onkologij Vol. 58; no. 5; p. 649
• Main Authors: Semënov, D Iu, Boriskova, M E, Zaraĭskiĭ, M I, Saburova, I Iu, Pankova, P A, Farafonova, U V, Bykov, M A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2012
• Subjects: Adenocarcinoma, Follicular - diagnosis; Adenocarcinoma, Follicular - genetics; Adenocarcinoma, Follicular - therapy; Adult; Biopsy, Fine-Needle; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - genetics; Carcinoma, Papillary - therapy; Diagnosis, Differential; Female; Glutamic Acid; Goiter - diagnosis; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf - genetics; Sensitivity and Specificity; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - genetics; Thyroid Neoplasms - therapy; Valine
• ISSN: 0507-3758

A possibility of detection of BRAF mutation has been studied by means of polymerase chain reaction in punctate from the thyroid node with the aim of diagnostics of high-differentiated cancer on pre-operative stage. A study includes 94 patients with nodal lesions of the thyroid. According to cytological investigation of material, received by fine-needle aspiration biopsy, papillary thyroid cancer was revealed in 47 patients, follicular tumor-in 35 and nodal colloid goiter in 12 patients. In case of papillary thyroid cancer data of genetic analysis showed the following indices of sensitivity, specificity and diagnostic accuracy: 86%, 100% and 92% correspondingly. Detection of BRAF mutation could be used in pre-operative differential diagnostics of high-differentiated cancer and benign nodal lesions of the thyroid.