Novel metabolically stable functionally-active mimetic of spermidine

Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine N1-acetyltransferase, or spermine synthase, but was capable to support the growth of DU145 cells with depleted polyamine pool. Such a combination of y-MeSpd p...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 37; no. 2; p. 253
Main Authors:	Khomutov, M A, Khivonen, M T, Simonian, A R, Vepsäläinen, Ĭ, Alkhonen, L, Kochetkov, S N, Keinänen, T A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2011
Subjects:	Acetyltransferases - metabolism Biomimetic Materials - chemical synthesis Cell Growth Processes - drug effects Cell Line, Tumor Humans Male Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Stability Spermidine - analogs & derivatives Spermidine - chemical synthesis Spermidine - metabolism Spermidine - pharmacology Spermine - metabolism Spermine Synthase - metabolism Substrate Specificity
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Summary:	Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine N1-acetyltransferase, or spermine synthase, but was capable to support the growth of DU145 cells with depleted polyamine pool. Such a combination of y-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
ISSN:	0132-3423