Noninvasive estimation of the oxygen state of experimental tumor by diffuse optical spectroscopy

The potentialities of diffuse optical spectroscopy for the noninvasive estimation of the oxygen state of experimental tumors have been demonstrated. The distribution of total, oxygenated and deoxygenated hemoglobin, as well as the level oxygen saturation of blood have been shown using two tumor mode...

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Bibliographic Details
Published in:	Biofizika Vol. 56; no. 2; p. 349
Main Authors:	Orlova, A G, Maslennikova, A V, Golubiatnikov, G Iu, Kamenskiĭ, V A, Shakhova, N M, Babaev, A A, Snopova, L B, Ivanova, I P, Plekhanov, V I, Prianikova, T I, Turchin, I V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2011
Subjects:	Animals Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oximetry - methods Oxygen - metabolism Oxygen Consumption Oxyhemoglobins - metabolism Rats
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Summary:	The potentialities of diffuse optical spectroscopy for the noninvasive estimation of the oxygen state of experimental tumors have been demonstrated. The distribution of total, oxygenated and deoxygenated hemoglobin, as well as the level oxygen saturation of blood have been shown using two tumor models differing in the histological structure and functional characteristics. The results obtained by the optical method have been verified by immunohistochemical examination of tissue specimens with the exogenous hypoxia marker pimonidazole.
ISSN:	0006-3029