Acidoketosis in a chronic alcoholic woman

A 37-year-old chronic alcoholic female was admitted with epigastric pain, complete anorexia, vomiting and diarrhoea. She was dehydrated, and had polypnoea. Laboratory investigations revealed severe metabolic acidosis (pH 7.14) with a major anion gap (37.4 mmol.l-1), and ketone bodies in blood and ur...

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Bibliographic Details
Published in:	Annales françaises d'anesthésie et de réanimation Vol. 10; no. 4; p. 398
Main Authors:	Staikowsky, F, Levy, I, Guidet, B, Gabillet, J M, Offenstadt, G
Format:	Journal Article
Language:	French
Published:	France 1991
Subjects:	Acid-Base Equilibrium Acidosis - etiology Acidosis - metabolism Acidosis - therapy Adult Alcoholism - complications Female Humans Ketosis Prognosis Water-Electrolyte Imbalance - etiology Water-Electrolyte Imbalance - therapy
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Summary:	A 37-year-old chronic alcoholic female was admitted with epigastric pain, complete anorexia, vomiting and diarrhoea. She was dehydrated, and had polypnoea. Laboratory investigations revealed severe metabolic acidosis (pH 7.14) with a major anion gap (37.4 mmol.l-1), and ketone bodies in blood and urine. Blood glucose concentration was 6.1 mmol.l-1, there was no glycosuria. Rehydration (2 l.day-1 of 5% glucose) together with sodium bicarbonate (500 ml of 1.4% sodium bicarbonate over the first four hours) normalized the pH (7.37). The ketone bodies disappeared on the following day. During the acute illness, were found high blood levels of glucagon and low levels of insulin. The diagnosis of alcoholic ketoacidosis, the pathogenesis of which remains unknown, is discussed.
ISSN:	0750-7658