Noncoenzyme function of vitamin PP and its biologically active derivatives: the current state of the problem

This review is devoted to the current state of investigations of vitamin PP and nicotinamide dinucleotides noncoenzyme functions. Particular attention has been focused on the role of these compounds in post-translation modification of proteins (mono- and poly-ADP-ribosylation), in regulation of gene...

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Bibliographic Details
Published in:	Ukrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 79; no. 5; p. 59
Main Authors:	Shymans'kyĭ, I O, Kuchmerovs'ka, T M
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 01-09-2007
Subjects:	Animals Calcium - metabolism Calcium Signaling - genetics Calcium Signaling - physiology Humans Niacinamide - genetics Niacinamide - metabolism Niacinamide - physiology Nucleotides - genetics Nucleotides - metabolism Nucleotides - physiology Synaptic Transmission - physiology
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Summary:	This review is devoted to the current state of investigations of vitamin PP and nicotinamide dinucleotides noncoenzyme functions. Particular attention has been focused on the role of these compounds in post-translation modification of proteins (mono- and poly-ADP-ribosylation), in regulation of gene activity, calcium homeostasis and Ca2+ signalling as well as in modulation of synaptic transmission. Biological significance of these processes in cell function was elicited. The role of deregulation of vitamin PP mediated signalling mechanisms involved in control over the cell function under conditions of different diseases was emphasized.