Endogenous intoxication parameters in the assessment of a risk for pneumonias in acute azaleptin intoxications

In cases of acute azaleptin poisoning (AAP), the parameters of endogenous intoxication (EI) were studied in patients both with complicated pneumonias and without them. The integral EI index endogenous intoxication coefficient (Cei) was developed, which simultaneously reflects the coupling capacity o...

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Bibliographic Details
Published in:	Klinicheskaia laboratornaia diagnostika no. 6; p. 28
Main Authors:	Matveev, S B, Il'iashenko, K K, Ermokhina, T V, Fedorova, N V, Belova, M V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-06-2007
Subjects:	Adult Antipsychotic Agents - blood Antipsychotic Agents - poisoning Clozapine - blood Clozapine - poisoning Female Humans Male Middle Aged Pneumonia - blood Pneumonia - chemically induced Pneumonia - diagnosis Risk Assessment Serum Albumin - analysis
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Summary:	In cases of acute azaleptin poisoning (AAP), the parameters of endogenous intoxication (EI) were studied in patients both with complicated pneumonias and without them. The integral EI index endogenous intoxication coefficient (Cei) was developed, which simultaneously reflects the coupling capacity of albumin of hydrophilic toxins and lipid peroxidation products: Cei (MMWP x MDA/EAC) x 1000, where MMWP is medium molecular-weight peptides; MDA is malonic dialdehyde; EAC is the effective albumin concentration. The use of Cei significantly enhances the efficiency of diagnosis of early-stage EI and provides a more objective assessment of therapy in AAP patients. EI is more severe when poisoning is concurrent with complicated pneumonias. Cei is of informative value in the assessment of a risk for pneumonias in AAP, which may be used in various emergencies accompanied by EI.
ISSN:	0869-2084