Synthesis and biological properties of 6-oxa-D-homo-8alpha analogues of steroid estrogens

Modifications of 6-oxa-D-homo-8alpha-analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other c...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 33; no. 3; p. 310
Main Authors:	Shavva, A G, Morozkina, S N, Ishchenko, I V, Eliseev, I I, Selivanov, S I, Abusalimov, Sh N, Selivanov, S S, Kameneva, I Iu, Eshchenko, N D
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2007
Subjects:	Animals Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Bone and Bones - anatomy & histology Bone and Bones - drug effects Cholesterol - blood Estrogens - chemical synthesis Estrogens - chemistry Estrogens - pharmacology Female Organ Size - drug effects Ovariectomy Rats Rats, Sprague-Dawley Receptors, Progesterone - biosynthesis Stereoisomerism Steroids - chemical synthesis Steroids - chemistry Steroids - pharmacology Structure-Activity Relationship Sulfatases - antagonists & inhibitors Triglycerides - blood Uterus - anatomy & histology Uterus - drug effects Uterus - metabolism
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Summary:	Modifications of 6-oxa-D-homo-8alpha-analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other compounds to the estrogen target organs.
ISSN:	0132-3423