Functional activity of phagocyte blood cells in pulmonary tuberculosis

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 79
• Main Authors: Filiniuk, O V, Urazova, O I, Novitskiĭ, V V, Strelis, A K, Zemlianaia, N A, Pirogova, N P, Voronkova, O V, Buĭnova, L N, Luk'ianova, T A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-01-2006
• Subjects: Adult; Antitubercular Agents - therapeutic use; Blood Cells; Female; Humans; Male; Middle Aged; Monocytes - metabolism; Neutrophils - immunology; Neutrophils - metabolism; Oxygen - metabolism; Phagocytosis; Receptors, Complement 3b - metabolism; Receptors, IgG - metabolism; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - immunology
• ISSN: 0372-9311

The characteristics of the functional activity of phagocyte blood cells in patients with destructive pulmonary tuberculosis caused by medicinal sensitive and medicinal resistant infective agents were studied. In the process of pulmonary tuberculosis, irrespective of the medicinal sensitivity of infective agents before and during treatment, a decrease in the phagocytic activity of neutrophil granulocytes and the level of the expression of Fcgamma- and C3b-receptors on monocytes with a simultaneous increase in the spontaneous production of oxygen metabolites in neutophils and a rise in the adsorptive capacity of monocytic cells were observed.