Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives

New 5-azole- and 5-oxime-substituted analogues of 2'-deoxyuridine are synthesized. The analogues with azole ring manifest low toxicities and antiherpetic activities on Vero cell culture, the imidazole derivative being the most active. The inhibitory effects of oximes of 5-formyl-deoxyuridine ar...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 31; no. 6; p. 616
Main Authors:	Ivanov, A V, Simonian, A R, Belanov, E F, Aleksandrova, L A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-2005
Subjects:	Acyclovir - pharmacology Animals Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Azoles - chemical synthesis Azoles - pharmacology Cell Survival - drug effects Cercopithecus aethiops Deoxyuridine - analogs & derivatives Deoxyuridine - chemical synthesis Deoxyuridine - pharmacology Herpesvirus 1, Human - drug effects Oximes - chemical synthesis Oximes - pharmacology Poxviridae - drug effects Vero Cells Virus Replication - drug effects
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Summary:	New 5-azole- and 5-oxime-substituted analogues of 2'-deoxyuridine are synthesized. The analogues with azole ring manifest low toxicities and antiherpetic activities on Vero cell culture, the imidazole derivative being the most active. The inhibitory effects of oximes of 5-formyl-deoxyuridine are comparable with those of the azole-containing nucleoside analogues, although their cytotoxicities are found to be higher; oxime of 5-formyldeoxyuridine is particularly toxic. The nucleoside analogues synthesized exhibit no marked activity on cell cultures infected with various variants of poxvirus. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2005, vol. 31, no. 6; see also http://www.maik.ru.
ISSN:	0132-3423