Determination of rifamycin B activity in culture liquids and in preparations with varying degrees of purity

A possibility of using the biological method of rifamycin B activity determination in the fermentation broth and dry preparations of various purity levels was studied. It was found that the biological method was useful only for determination of rifamycin B activity in preparations containing not les...

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Bibliographic Details
Published in:	Antibiotiki Vol. 21; no. 8; p. 685
Main Authors:	Makarova, R A, Rezvan, S P, Dzegilenko, N B, Birlova, L V, Chaĭkovskaia, S M
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1976
Subjects:	Agar Culture Media - pharmacology Drug Contamination Hydrogen-Ion Concentration Microbial Sensitivity Tests Rifamycins - pharmacology Spectrophotometry
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Summary:	A possibility of using the biological method of rifamycin B activity determination in the fermentation broth and dry preparations of various purity levels was studied. It was found that the biological method was useful only for determination of rifamycin B activity in preparations containing not less than 850 gamma/mg of the main product. When the activity of rifamycin B was determined in the fermentation broth and crude preparations containing less than 800 gamma/mg of the main product, the results of the biological assay were always higher as compared to those of spectrophotometrical estimation. It was accounted for the effect of other rifamycin types possessing high biological activity.
ISSN:	0003-5637