Neuroleptic malignant syndrome: case report with recurrence associated with the use of olanzapine

The neuroleptic malignant syndrome (NMS) consists in an idiosyncratic reaction to neuroleptic drugs, probably related to a blockage of dopamine receptors in basal ganglia. Research criteria for diagnosing NMS from DSM-IV require severe rigidity and fever accompanied by 2 of 10 minor features includi...

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Bibliographic Details
Published in:	Arquivos de neuro-psiquiatria Vol. 56; no. 4; p. 833
Main Authors:	Hanel, R A, Sandmann, M C, Kranich, M, De Bittencourt, P R
Format:	Journal Article
Language:	Portuguese
Published:	Brazil 01-12-1998
Subjects:	Adult Antipsychotic Agents - adverse effects Benzodiazepines Chlorpromazine - adverse effects Haloperidol - adverse effects Humans Male Neuroleptic Malignant Syndrome - diagnosis Neuroleptic Malignant Syndrome - drug therapy Olanzapine Pirenzepine - adverse effects Pirenzepine - analogs & derivatives Recurrence
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Summary:	The neuroleptic malignant syndrome (NMS) consists in an idiosyncratic reaction to neuroleptic drugs, probably related to a blockage of dopamine receptors in basal ganglia. Research criteria for diagnosing NMS from DSM-IV require severe rigidity and fever accompanied by 2 of 10 minor features including diaphoresis, dysphagia, tremor, incontinence, altered mentation, mutism, tachycardia, elevated or labile blood pressure, leukocytosis and elevation of creatine phosphokinase. From a clinical point of view, the NMS may range a large spectrum of presentations. Haloperidol is the most frequent drug associated with this syndrome. We report the case of a 30 year-old man who developed NMS at two different occasions, the first related to haloperidol and chlorpromazine and the second related to olanzapine, to our knowledge without previous mention in the indexed literature.
ISSN:	0004-282X