CSF I+/--synuclein concentrations do not fluctuate over hours and are not correlated to amyloid I super(2) in humans

• Published in: Neuroscience letters Vol. 504; no. 3; pp. 336 - 338
• Main Authors: Spies, Petra E, Slats, Diane, Rikkert, Marcel GMOlde, Tseng, Jack, Claassen, Jurgen AHR, Verbeek, Marcel M
• Format: Journal Article
• Language: English
• Published: 31-10-2011
• ISSN: 0304-3940
• DOI: 10.1016/j.neulet.2011.09.063

Reports on the value of cerebrospinal fluid (CSF) I+/--synuclein as a biomarker for dementia with Lewy bodies and Parkinson disease are contradicting. This may be explained by fluctuating CSF I+/--synuclein concentrations over time. Such fluctuations have been suggested for CSF amyloid I super(2) concentrations. Furthermore, a physiological relationship between I+/--synuclein and amyloid I super(2) has been suggested based on in vitro research. We performed repeated CSF sampling in healthy elderly and AD patients and showed that sinusoidal fluctuations in CSF I+/--synuclein concentrations were not present. Furthermore, we did not find evidence for an interaction between amyloid I super(2) and I+/--synuclein concentrations in CSF.