Hypertriglyceridemia-induced acute necrotizing pancreatitis: Poor clinical outcomes requiring revisiting management modalities

• Published in: JGH open : an open access journal of gastroenterology and hepatology Vol. 8; no. 4; p. e13061
• Main Authors: Abboud, Yazan, Shah, Meet, Simmons, Benjamin, Mandava, Kranthi, Morales, John E M, Jaber, Fouad, Alsakarneh, Saqer, Ismail, Mohamed, Hajifathalian, Kaveh
• Format: Report
• Language: English
• Published: 01-04-2024
• ISSN: 2397-9070
• DOI: 10.1002/jgh3.13061

Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is the third most common cause of AP after gallstones and alcohol. Supportive measures, intravenous insulin, and plasmapheresis are possible treatment modalities for HTG-AP; however, definitive guidelines evaluating the best therapeutic approach are not clearly established. We present a rare case of a 42-year-old male without known comorbidities who was found to have HTG-AP. Despite early initiation of intravenous insulin and plasmapheresis and the initial decline in his triglycerides level, his condition was complicated by necrotizing pancreatitis and subsequent multi-organ failure. Future studies are warranted to evaluate the role of plasmapheresis in HTG-AP and its efficacy.