First-in-human liver transplantation from a centenarian deceased donor after brain death

• Published in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Vol. 24; no. 2; pp. 304 - 307
• Main Authors: De Simone, Paolo, Ghinolfi, Davide, Palladino, Simona, Catalano, Gabriele, Martinelli, Caterina, Ducci, Juri, Bronzoni, Jessica, Tincani, Giovanni, Balzano, Emanuele, Carrai, Paola, Petruccelli, Stefania, Campani, Daniela, Crocetti, Laura, Lazzeri, Chiara, Biancofiore, Giandomenico, Peris, Adriano
• Format: Report
• Language: English
• Published: 01-02-2024
• ISSN: 1600-6143
• DOI: 10.1016/j.ajt.2023.09.014

Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant immunotherapy. Nine months after the transplant, the patient is alive with a functioning graft and no evidence of acute rejection or tumor recurrence.