Cyclic diarylheptanoids as Na super(+)-glucose cotransporter (SGLT) inhibitors from Acer nikoense
Two cyclic diarylheptanoids, acerogenins A ( 1) and B ( 2) have been isolated from the bark of Acer nikoense as inhibitors of Na super(+)-glucose cotransporter (SGLT). Acerogenins A ( 1) and B ( 2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on...
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| Published in: | Bioorganic & medicinal chemistry letters Vol. 20; no. 3; pp. 1070 - 1074 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-02-2010
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| Abstract | Two cyclic diarylheptanoids, acerogenins A ( 1) and B ( 2) have been isolated from the bark of Acer nikoense as inhibitors of Na super(+)-glucose cotransporter (SGLT). Acerogenins A ( 1) and B ( 2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed. |
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| AbstractList | Two cyclic diarylheptanoids, acerogenins A ( 1) and B ( 2) have been isolated from the bark of Acer nikoense as inhibitors of Na super(+)-glucose cotransporter (SGLT). Acerogenins A ( 1) and B ( 2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed. |
| Author | Hirasawa, Yusuke Sato, Seizo Takeo, Jiro Shiro, Motoo Morita, Hiroshi Deguchi, Jun Aoyama, Chihiro Motegi, Yusuke |
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| Title | Cyclic diarylheptanoids as Na super(+)-glucose cotransporter (SGLT) inhibitors from Acer nikoense |
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