Cyclic diarylheptanoids as Na super(+)-glucose cotransporter (SGLT) inhibitors from Acer nikoense

Two cyclic diarylheptanoids, acerogenins A ( 1) and B ( 2) have been isolated from the bark of Acer nikoense as inhibitors of Na super(+)-glucose cotransporter (SGLT). Acerogenins A ( 1) and B ( 2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 20; no. 3; pp. 1070 - 1074
Main Authors:	Morita, Hiroshi, Deguchi, Jun, Motegi, Yusuke, Sato, Seizo, Aoyama, Chihiro, Takeo, Jiro, Shiro, Motoo, Hirasawa, Yusuke
Format:	Journal Article
Language:	English
Published:	01-02-2010
Subjects:	Acer
Online Access:	Get full text
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Summary:	Two cyclic diarylheptanoids, acerogenins A ( 1) and B ( 2) have been isolated from the bark of Acer nikoense as inhibitors of Na super(+)-glucose cotransporter (SGLT). Acerogenins A ( 1) and B ( 2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2009.12.036