Transition state isosteres of the gamma -glutamyl peptide bond hydrolysis: synthesis and characterization of the gradient [CH2NH] pseudopeptide analogue of glutathione

Transition state isosteres of the gamma -glutamyl peptide bond hydrolysis: synthesis and characterization of the gradient [CH2NH] pseudopeptide analogue of glutathione

The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the -Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms.

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Bibliographic Details
Published in:Journal of peptide science Vol. 10; no. 2; pp. 109 - 114
Main Authors: Cacciatore, Ivana, Di Stefano, Antonio, Luisi, Grazia, Pinnen, Francesco, Sozio, Piera
Format: Journal Article
Language:English
Published: 01-02-2004
Online Access:Get full text
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Description
Summary:The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the -Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms.
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SourceType-Scholarly Journals-1
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ISSN:1075-2617
DOI:10.1002/psc.501