Further Insights in the Mechanisms of lnterleukin-1^b Stimulation of Osteoprotegerin in Osteoblast-Like Cells

Further Insights in the Mechanisms of lnterleukin-1^b Stimulation of Osteoprotegerin in Osteoblast-Like Cells

The mechanisms of IL-1^b stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-^KB was not necessary for this regulation. We also found that OPG production after IL-1^b stimulation was not sufficient to block TRAIL-induced apoptosis in MG-63 ce...

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Bibliographic Details
Published in:Journal of bone and mineral research Vol. 22; no. 9; pp. 1350 - 1361
Main Authors: Lambert, C, Oury, C, Dejardin, E, Chariot, A, Piette, J, Malaise, M, Merville, M-P, Franchimont, N
Format: Journal Article
Language:English
Published: 01-09-2007
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Summary:The mechanisms of IL-1^b stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-^KB was not necessary for this regulation. We also found that OPG production after IL-1^b stimulation was not sufficient to block TRAIL-induced apoptosis in MG-63 cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0884-0431
DOI:10.1359/jbmr.070508