Expression and Clinical Significance of Artemin Protein in Triple-negative and Nontriple-negative Breast Cancer Tissues

• Published in: Zhongliu fangzhi yanjiu Vol. 43; no. 6
• Main Authors: Yang, Meng, Dai, Dianlu, Liu, Licheng
• Format: Journal Article
• Language: Chinese
• Published: 01-01-2016
• ISSN: 1000-8578

Objective To investigate the expression of Artemin protein in triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBC) tissues, and to further explore its relationship with clinical pathology and the prognosis of tumor, to provide powerful evidence for judging biological behaviour and evaluating the prognosis. Methods According to the criteria, 240 cases of breast cancer (120 cases of TNBC, 120 cases of non-TNBC, respectively) were selected randomly and admitted to Cangzhou Central Hospital of Hebei Medical University from July 2005 to July 2009. The expression of Artemin was detected in tumor tissues. All data were analyzed using t test and chi-square test, and the survival of patients was analyzed using the life table and Kaplan-Meier curves. The COX proportional hazards model was also used for the prognosis. Results The positive expression rate of Artemin protein was 61.7%(148/240). The positive rate of Artemin in TNBC tissues was higher than that in non-TNBC tissues [82.5%(99/