CD83 Regulates the Development of Cellular Immunity

• Published in: The Journal of immunology (1950) Vol. 168; no. 6; pp. 2599 - 2602
• Main Authors: Scholler, N, Hayden-Ledbetter, M, Dahlin, A, Hellstroem, I, Hellstroem, KE, Ledbetter, JA
• Format: Journal Article
• Language: English
• Published: 15-03-2002
• Subjects: CD83 antigen
• ISSN: 0022-1767

We recently found that human CD83, a marker of mature dendritic cells, is an adhesion receptor that binds to resting monocytes and a subset of activated CD8 super(+) T cells. We injected CD83-Ig into mice transplanted with the immunogenic P815 mastocytoma and showed that it significantly enhanced the rate of tumor growth and inhibited the development of cytotoxic T cells. In contrast, mice immunized with CD83-transfected K1735 cells, a poorly immunogenic melanoma, could prevent the outgrowth of wild-type K1735 cells. Studies performed in vitro with human PBL showed that coimmobilized CD83-Ig and anti-CD3 enhanced T cell proliferation and increased the proportion of CD8 super(+) T cells. CD83-transfected B-lymphoblastoid T51 cells stimulated T cell proliferation more effectively than untransfected T51 cells in MLR cultures and increased the generation of cytolytic T cells. We conclude that CD83 is a functionally important receptor that can regulate the development of cellular immunity by interacting with its ligand(s).