Iron Metal-Organic Frameworks MIL-88B and NH sub(2)-MIL-88B for the Loading and Delivery of the Gasotransmitter Carbon Monoxide

• Published in: Chemistry : a European journal Vol. 19; no. 21; pp. 6785 - 6790
• Main Authors: Ma, Mingyan, Noei, Heshmat, Mienert, Bernd, Niesel, Johanna, Bill, Eckhard, Muhler, Martin, Fischer, Roland A, Wang, Yuemin, Schatzschneider, Ulrich, Metzler-Nolte, Nils
• Format: Journal Article
• Language: English
• Published: 01-05-2013
• Subjects: Biocompatibility; Carbon monoxide; Carriers; Crystallinity; Crystals; Metal-organic frameworks; Myoglobin; Ultrahigh vacuum; Vehicles
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201201743

Crystals of MIL-88B-Fe and NH sub(2)-MIL-88B-Fe were prepared by a new rapid microwave-assisted solvothermal method. High-purity, spindle-shaped crystals of MIL-88B-Fe with a length of about 2 mu m and a diameter of 1 mu m and needle-shaped crystals of NH sub(2)-MIL-88B-Fe with a length of about 1.5 mu m and a diameter of 300nm were produced with uniform size and excellent crystallinity. The possibility to reduce the as-prepared frameworks and the chemical capture of carbon monoxide in these materials was studied by insitu ultrahigh vacuum Fourier-transform infrared (UHV-FTIR) spectroscopy and Mossbauer spectroscopy. CO binding occurs to unsaturated coordination sites (CUS). The release of CO from the as-prepared materials was studied by a myoglobin assay in physiological buffer. The release of CO from crystals of MIL-88B-Fe with t sub(1/2)=38min and from crystals of NH sub(2)-MIL-88B-Fe with t sub(1/2)=76min were found to be controlled by the degradation of the MIL materials under physiological conditions. These MIL-88B-Fe and NH sub(2)-MIL-88B-Fe materials show good biocompatibility and have the potential to be used in pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter carbon monoxide. Send and deliver: Spindle-shaped crystals of MIL-88B-Fe with a length of about 2 mu m and a diameter of 1 mu m and needle-shaped crystals of NH sub(2)-MIL-88B-Fe with a length of about 1.5 mu m and a diameter of 300nm were produced with uniform size and excellent crystallinity (see picture). These materials show good biocompatibility and have potential pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter CO.