One pot four-component reaction for the efficient synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole]-3'-carboxy late derivatives

• Published in: Tetrahedron letters Vol. 54; no. 40; pp. 5434 - 5440
• Main Authors: Pal, Suman, Khan, MdNasim, Karamthulla, Shaik, Abbas, Sk Jahir, Choudhury, Lokman H
• Format: Journal Article
• Language: English
• Published: 01-10-2013
• Subjects: Carbon-carbon composites; Derivatives; Hydrazines; Malononitrile; Synthesis (chemistry); Tetrahedrons
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2013.07.117

A novel one pot protocol has been developed to synthesize various spiro[indoline-3,4'-pyrano[2,3-c]pyrazole]-3'-carboxy late derivatives from the four-component reaction of isatin, malononitrile, hydrazine derivatives and dialkyl acetylenedicarboxylates. In this process two C-C bonds, two C-N bonds and one C-O bond have formed in one pot. The notable features of this protocol are simple and environmentally benign reaction condition, easy isolation of products, applicable to a wide range of readily available starting materials and good yields.