Functional evidence for involvement of bumetanide-sensitive Na super(+)K super(+)2Cl super(-) cotransport in the hepatoportal Na super(+) receptor of the Sprague-Dawley rat
To investigate mechanisms involved in hepatoportal Na super(+) sensing, responses of hepatic afferent nerve activity (HANA) to intraportal hypertonic NaCl injection were measured before, and after, intraportal infusion of inhibitors of Na super(+) transport systems. HANA increased in response to the...
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| Published in: | Neuroscience letters Vol. 264; no. 1-3; pp. 65 - 68 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-04-1999
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| Online Access: | Get full text |
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| Summary: | To investigate mechanisms involved in hepatoportal Na super(+) sensing, responses of hepatic afferent nerve activity (HANA) to intraportal hypertonic NaCl injection were measured before, and after, intraportal infusion of inhibitors of Na super(+) transport systems. HANA increased in response to the intraportal injection of 0.75 M NaCl in a dose-dependent manner. The HANA response was not affected by amiloride or 4-acetamido-4 theta -isothiocyanato-stilbene-2,2 theta -disulfonic acid (SITS), but was suppressed in a dose-dependent manner by intraportal infusion of ouabain, furosemide, or bumetanide. These results indicate that the hepatoportal Na super(+) receptor senses the Na super(+) concentration via the bumetanide-sensitive Na super(+)K super(+)2Cl super(-) cotransporter. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/S0304-3940(99)00157-3 |